Long before Will Forte, Vincent Price was the last man on earth, although he never used a swimming pool as a toilet. Instead, Price arms himself with garlic, mirrors and wooden stakes as he battles the plague and the undead.
Vincent Price as Dr. Robert Morgan (in others as Robert Neville)
Franca Bettoia as Ruth Collins
Emma Danieli as Virginia Morgan
Giacomo Rossi-Stuart as Ben Cortman
Umberto Raho as Dr. Mercer
Christi Courtland as Kathy Morgan
Antonio Corevi as the Governor
Ettore Ribotta as the TV Reporter Rolando De Rossi
Carolyn De Fonseca dubbed for Franca Bettoia's voice in the English release of the film. She was uncredited.
Giuseppe Mattei, as the leader of the survivors, was also uncredited.